A Migraine Is Not Just a Headache. NAPRIDOM Treats the Pain and the Nausea Together — Because Managing One Without the Other Is Not Enough.

Naproxen 500mg

COX-1 & COX-2 Inhibitor · Long-Acting · Anti-Inflammatory · Analgesic · Antipyretic

Naproxen is a propionic acid-class NSAID that works by inhibiting both Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) enzymes — the enzymes responsible for converting arachidonic acid into prostaglandins. Prostaglandins are the primary chemical mediators of pain, inflammation, fever and vascular changes. In migraine specifically, prostaglandins cause intracranial blood vessel dilation and neurogenic inflammation — producing the characteristic throbbing, pulsating pain of a migraine attack.

By blocking both COX enzymes, Naproxen reduces prostaglandin synthesis throughout the body — producing analgesic, anti-inflammatory and antipyretic effects. Its key clinical advantage over shorter-acting NSAIDs like Ibuprofen is its long half-life of 12–17 hours, providing sustained pain relief from a single dose — ideal for migraine attacks that can last for hours to days. At 500mg, NAPRIDOM provides the full therapeutic dose validated in migraine treatment guidelines.

Domperidone 10mg

Dopamine D2 Antagonist · Antiemetic · Prokinetic · Gastric Motility Restoration

Domperidone is a dopamine D2 receptor antagonist — but unlike Metoclopramide (another dopamine antagonist commonly used as an antiemetic), Domperidone acts primarily at the peripheral dopamine receptors of the gastrointestinal tract and at the chemoreceptor trigger zone (CTZ) in the brain — without significantly crossing the blood-brain barrier. This gives Domperidone its antiemetic and prokinetic effects with a significantly lower risk of the central nervous system side effects (extrapyramidal reactions, sedation) associated with centrally-acting dopamine antagonists.

In the context of migraine treatment, Domperidone’s role is dual and critically important. By blocking D2 receptors in the CTZ, it prevents the nausea and vomiting signal from reaching the vomiting centre — directly suppressing migraine-associated nausea. Simultaneously, by blocking peripheral D2 receptors in the gut wall, it restores normal gastric motility — reversing the gastric stasis of migraine and ensuring that Naproxen is propelled from the stomach into the small intestine where it can be properly absorbed. This prokinetic action effectively converts the oral Naproxen from a poorly-absorbed migraine treatment into one that reaches the bloodstream at the right concentration, at the right time.

Acute Migraine With Nausea or Vomiting

The primary and most important indication for NAPRIDOM. Migraine attacks accompanied by nausea — which describes the majority of moderate-to-severe migraine episodes — are precisely the clinical situation this combination addresses. NAPRIDOM should be taken at the earliest sign of an attack — ideally at the very onset of headache, before the pain becomes severe and before gastric stasis is fully established. Earlier administration consistently produces better outcomes because Naproxen is absorbed before the gastric stasis reaches its maximum, and Domperidone prevents the nausea from becoming established.

Menstrual Migraine and Hormonal Migraine

Menstrual migraine — migraine attacks triggered by the cyclical drop in oestrogen around the menstrual period — is one of the most common and most severe migraine presentations in Indian women. These attacks are typically longer, more intense and more resistant to standard treatment than non-menstrual migraines. Naproxen’s long half-life (12–17 hours) gives it a particular advantage in menstrual migraine — sustained anti-prostaglandin effect across the duration of the attack — and its anti-inflammatory action also addresses the uterine prostaglandin excess that drives menstrual cramping simultaneously.

Dysmenorrhoea (Menstrual Cramps)

Primary dysmenorrhoea — painful menstrual cramps caused by excessive uterine prostaglandin production driving sustained, painful uterine contractions — is one of the most common reasons women seek over-the-counter and prescription pain relief in India. Naproxen’s dual COX inhibition reduces uterine prostaglandin synthesis directly, relieving cramping and reducing menstrual blood flow. Domperidone addresses the nausea that frequently accompanies severe dysmenorrhoea, completing a comprehensive single-tablet approach to period pain management.

Inflammatory Joint Pain — Rheumatoid Arthritis and Osteoarthritis

As a potent dual COX inhibitor, Naproxen is indicated for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and acute gout flares — providing meaningful analgesic and anti-inflammatory relief. In patients with these conditions who also experience NSAID-related nausea or gastric discomfort, the Domperidone component of NAPRIDOM adds prokinetic support that reduces GI symptoms and improves medication tolerability. This makes NAPRIDOM particularly appropriate for older patients with inflammatory joint disease who are prone to NSAID-related gastric complaints.

Post-Operative and Acute Musculoskeletal Pain With Nausea

In acute musculoskeletal pain conditions — tendinitis, bursitis, acute back pain, sports injuries — where nausea is present as a consequence of pain severity or co-prescribed medications, NAPRIDOM provides dual-action relief. The Domperidone component addresses nausea without sedation, while Naproxen’s sustained 12–17 hour action reduces the need for frequent redosing during acute pain episodes.